Live Webinar on PURE EP 2.0 Study Results • November 18, 2021

PURE EP™ System 

More information, better decisions

The PURE EP™ System sets a new standard in electrophysiology by providing essential intracardiac signals with high clinical value in all types of cardiac ablations.

Now combining the best-in-class intracardiac signal acquisition technology with the new PURE EP™ Software Version 4 designed around 4 key procedural steps.

More than 1,500 patient cases have been conducted using the PURE EP™ System by 70 physicians in thirteen clinical sites to date.

Clinical Data Acquired by PURE EP™ Published in the Journal of Cardiovascular Electrophysiology

An article titled, "Evaluation of a novel cardiac signal processing system for electrophysiology procedures: the PURE EP 2.0 study" has been published in the Journal of Cardiovascular Electrophysiology and is available electronically. The PURE EP™ System is validated in the multi-center study as superior to conventional sources of intracardiac signals

Press Release

BioSig Selects Plexus Corp. as its Manufacturing Partner for PURE EP™

BioSig announced that the Company entered into a manufacturing and professional services agreement with Plexus Corp, a global leader in complex product design, supply chain, manufacturing, and aftermarket services to support the Company’s growth

Press Release

BioSig Appoints Medical Device Industry Leader James J. Barry, Ph.D. to its Board of Directors

Former President and CEO at InspireMD and Sr. Vice President of Corporate Technology at Boston Scientific joins as an Independent Director as BioSig expands clinical footprint with its signal processing technology for arrhythmia care.

Press Release

BioSig Adds St. Elizabeth’s Medical Center to Roster of Premium Medical Institutions Utilizing PURE EP™

BioSig announced the Company would be installing a PURE EP(tm) System for evaluation at St. Elizabeth’s Medical Center in Boston, MA. The Company expands into exploration of its novel signal processing technology in physiologic pacing procedures.

Press Release

Bioelectronic Medicine:
The Leading Edge of Healthcare

  • Bioelectronic medicine is a new, rapidly growing field of healthcare that explores how targeted electrical signals in the body can help to diagnose and treat a wide range of diseases, from diabetes to depression.

  • BioSig aims to play a vital role in the field of bioelectronic medicine, based on our unique enabling technology and core competency in signal processing. Our initial focus is on heart disease and the fast-growing electrophysiology device market.

The Need to Improve Arrhythmia Treatment

Heart Disease Is the
#1 Cause of Death

Arrhythmia, a common cardiac condition, causes the heart to beat too quickly, too slowly, or erratically. New signal processing technologies could play a key role in enhancing outcomes from one of the most important treatments for arrhythmia: catheter ablation.

Challenging, Costly Conditions

Challenging, Costly Conditions

The health and economic impacts of arrythmia are immense. The most common arrhythmia, atrial fibrillation (AFib), affects 33 million people worldwide* – generating annual healthcare costs of $15,000 to $25,000 per patient*. 

*Worldwide Epidemiology of Atrial Fibrillation in the journal Circulation, 2013; “Healthcare Costs Drop Sharply after Successful Ablation,” Marlene Busko, Medscape, May 4, 2016

Barriers to Treatment Efficacy

Barriers to Treatment Efficacy

Treatment of AFib and ventricular tachycardia typically starts with drug therapy, which is often ineffective, particularly in the later stages of heart disease. Catheter ablation often fails, leading to costly repeat procedures.

The Importance of Signal Clarity

The Importance of Signal Clarity

Clearer signal information may help physicians work faster and more accurately during catheter ablation.  One of the main reasons for low ablation success rates is unreliable information – specifically, the inability to differentiate between the clean signal and lab noise. 

PURE EP™: A Signal Processing Solution

PURE EP™: A Signal Processing Solution

By improving signal clarity, BioSig’s PURE EP™ System has the potential to deliver valuable advances in electrophysiology procedures. Clinical data acquired by the PURE EP™ System in a multi-center study at Texas Cardiac Arrhythmia Institute at St. David’s Medical Center, Mayo Clinic Jacksonville, and Massachusetts General Hospital was recently published in the Journal of Cardiovascular Electrophysiology. Study results showed 93% consensus across the blinded reviewers with a 75% overall improvement in intracardiac signal quality and confidence in interpreting PURE EP™ signals over conventional sources. Learn more from our physician users.

How Does Pure EP™ Work?

Strong Commitment
to Research

BioSig is working with leading experts and organizations to develop additional features of PURE EP™ and explore signal processing applications in disease areas beyond arrhythmia.

Key Scientific Publications

We’re proud of our high success rate for peer-reviewed publications in some of the leading medical journals. These publications provide early evidence that PURE EP™ could offer valuable improvements in signal clarity during electrophysiology procedures.  

Browse Our Publications

Looking Beyond Arrhythmia

In 2017, BioSig signed a 10-year strategic collaboration with experts at Mayo Clinic to jointly develop our signal processing technology. These experts see the potential for our technology to help them electrically map the entire body, possibly leading to diagnosis and development of new therapies in other disease areas – for example, neurology and ophthalmology.

Learn About Our Partnerships