PURE EP™ System 

More information, better decisions

The PURE EP™ System sets a new standard in electrophysiology by providing essential intracardiac signals with high clinical value in all types of cardiac ablations.

Now combining the best-in-class intracardiac signal acquisition technology with the new PURE EP™ Software Version 4 designed around 4 key procedural steps.

More than 940 patient cases have been conducted using the PURE EP™ System by 52 physicians in nine clinical sites to date.

PURE EP™ to be Featured in Two Clinical and Scientific Presentations during Heart Rhythm 2021 convention

Abstracts are due to be presented by physician users and research investigators from two leading institutions. The annual Heart Rhythm 2021 convention takes place on July 28-31, 2021, at the Boston Convention and Exhibition Center in Boston, MA. The Company will be exhibiting at booth 849.

Press Release

BioSig Technologies, Inc. to Present New Clinical Data at Heart Rhythm 2021 Annual Convention

Company’s conference program to include physician presentations and new technology demonstrations for its proprietary signal processing system for arrhythmia care. The Heart Rhythm 2021 convention is due to take place on July 28-31, 2021 at the Boston Convention and Exhibition Center in Boston, MA.

Press Release

BioSig’s PURE EP™ System Evaluated with Patients at Mayo Clinic in Arizona

Physicians at Mayo Clinic’s campus in Phoenix, Arizona have started using the Company’s PURE EP(tm) System in the patient cases treating cardiac arrhythmias. The 30-day clinical evaluation of the PURE EP(tm) System is being conducted by the cardiac electrophysiologists Win-Kuang Shen, M.D., Hichan El Masry, M.D., Arturo Valverde, M.D. and Luis Scott, M.D.

Press Release

BioSig Completes Enrollment in the PURE EP 2.0 Clinical Study

51 patients undergoing elective cardiac ablation treatments were enrolled in the trial at Mayo Clinic, Massachusetts General Hospital, and St. David’s Medical Center. The trial is designed to demonstrate the quality and clinical value of the PURE EPTM signals when compared to conventional sources of cardiac signals.

Press Release

Bioelectronic Medicine:
The Leading Edge of Healthcare

  • Bioelectronic medicine is a new, rapidly growing field of healthcare that explores how targeted electrical signals in the body can help to diagnose and treat a wide range of diseases, from diabetes to depression.

  • BioSig aims to play a vital role in the field of bioelectronic medicine, based on our unique enabling technology and core competency in signal processing. Our initial focus is on heart disease and the fast-growing electrophysiology device market.

The Need to Improve Arrhythmia Treatment

Heart Disease Is the
#1 Cause of Death

Arrhythmia, a common cardiac condition, causes the heart to beat too quickly, too slowly, or erratically. New signal processing technologies could play a key role in enhancing outcomes from one of the most important treatments for arrhythmia: catheter ablation.

Challenging, Costly Conditions

Challenging, Costly Conditions

The health and economic impacts of arrythmia are immense. The most common arrhythmia, atrial fibrillation (AFib), affects 33 million people worldwide* – generating annual healthcare costs of $15,000 to $25,000 per patient*. 

*Worldwide Epidemiology of Atrial Fibrillation in the journal Circulation, 2013; “Healthcare Costs Drop Sharply after Successful Ablation,” Marlene Busko, Medscape, May 4, 2016

Barriers to Treatment Efficacy

Barriers to Treatment Efficacy

Treatment of AFib and ventricular tachycardia typically starts with drug therapy, which is often ineffective, particularly in the later stages of heart disease. Catheter ablation often fails, leading to costly repeat procedures.

The Importance of Signal Clarity

The Importance of Signal Clarity

Clearer signal information may help physicians work faster and more accurately during catheter ablation.  One of the main reasons for low ablation success rates is unreliable information – specifically, the inability to differentiate between the clean signal and lab noise. 

PURE EP™: A Signal Processing Solution

PURE EP™: A Signal Processing Solution

By improving signal clarity, BioSig’s PURE EP™ System has the potential to deliver valuable advances in electrophysiology procedures. We recently conducted first clinical cases at the Texas Cardiac Arrhythmia Institute under the leadership of Andrea Natale, M.D., F.A.C.C., F.H.R.S., F.E.S.C., Executive Medical Director, Texas Cardiac Arrhythmia Institute at St. David’s Medical Center. According to Dr. Natale, early results suggested improved cardiac signal detection and fidelity - click here to read the announcement.

How Does Pure EP™ Work?

Strong Commitment
to Research

BioSig is working with leading experts and organizations to develop additional features of PURE EP™ and explore signal processing applications in disease areas beyond arrhythmia.

Key Scientific Publications

We’re proud of our high success rate for peer-reviewed publications: 9 of the 10 publications we’ve submitted to date have been accepted. These publications provide early evidence that PURE EP™ could offer valuable improvements in signal clarity during electrophysiology procedures.  

Browse Our Publications

Looking Beyond Arrhythmia

In 2017, BioSig signed a 10-year strategic collaboration with experts at Mayo Clinic to jointly develop our signal processing technology. These experts see the potential for our technology to help them electrically map the entire body, possibly leading to diagnosis and development of new therapies in other disease areas – for example, neurology and ophthalmology.

Learn About Our Partnerships